The American Society of Regional Anesthesia and Pain Medicine has published a practice advisory on local anesthetic systemic toxicity (LAST) called “Guidelines for the Management of Severe Local ...

Over the last decade, poisonings and deaths linked to the use of local anesthetics have decreased. Even so, poisonings from one commonly used anesthetic, lidocaine, have increased in the United States ...

Lipid emulsion therapy has emerged over the past two decades as a life-saving intervention for local anaesthetic systemic toxicity (LAST). Intravenous administration of a triglyceride-rich emulsion ...

Michael Fettiplace, M.D., from the University of Illinois at Chicago, and colleagues analyzed reports of local anesthetic poisoning and mortality from the American Poison Centers National Poison Data ...

Over the last decade, poisonings and deaths linked to the use of local anesthetics have decreased. Even so, poisonings from one commonly used anesthetic, lidocaine, have increased in the United States ...

Pharmaceutical company Teligent has recalled some of its topical lidocaine numbing product due to 'super potency,' meaning it is stronger than anticipated. This super potency can, according to the ...

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and ...

Deaths from lidocaine poisonings more than doubled since 2010, calls to poison control centers suggested. Calls about local anesthetic poisonings decreased by 23%, mainly due to fewer non-lidocaine ...

Nanoparticle-based systems for local anaesthesia harness submicrometre carriers to deliver anaesthetic agents directly to peripheral nerves or tissue sites, thereby prolonging analgesic effect while ...

A new self-assembling drug delivery system releases the nerve-blocker tetrodotoxin more slowly and with less toxicity than direct injection of the anesthetic compound in rats. A team led by Daniel S.