IRI is a shared pathological process in myocardial infarction, ischaemic stroke, acute kidney injury, lung injury, and graft dysfunction after transplantation.

Alternative model systems to study ischemia-reperfusion are needed to support a wide range of disease-related investigations in the life sciences. Ischemia and reperfusion are relevant to many disease ...

The damage to the heart caused by a myocardial infarction is not just a result of ischemia caused by the blocked artery but is also brought about by bleeding in the myocardium after the artery has ...

In patients with acute ischaemic stroke due to anterior-circulation large-vessel occlusion achieving successful reperfusion, ...

Skin wounds from ischemia-reperfusion injuries -- tissue damage caused by blood returning to tissues after a period of oxygen deprivation -- may not heal appropriately in some patients, owing to ...

A University of South Florida Health (USF Health) preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury—a ...

Every year, 500,000 people in the United States have an ST-elevation myocardial infarction. 1 Timely and effective reperfusion with the use of either primary percutaneous coronary intervention (PCI) ...

Under ischemic conditions, the deficiency of oxygenated blood supply to the myocardium makes the energy requirements of the heart impossible to satisfy. Several metabolic alterations derive from ...

Restoring blood flow can save tissue after heart attack, stroke, transplantation, and severe injury, but it can also trigger ...