A study found that spop mutations increase prostate cancer sensitivity to ferroptosis, while chd1 deletions reduce vulnerability. Statins restored sensitivity in preclinical models, suggesting ...
Scientists have captured the 3D structure of SPOP, revealing how mutations in previously unappreciated regions fuel cancer. SPOP is the most mutated protein in prostate cancer and plays a role in ...
Multiple studies have determined that speckle-type POZ protein (SPOP) could suppress tumorigenesis in several types of human malignancies, including prostate, lung, gastric, liver, colon, and ...
SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely ...
Cryo-electron microscopy (cryo-EM) was used by researchers at St. Jude Children's Research Hospital to capture the first 3D structure of the entire SPOP assembly. The findings were published in the ...
SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely ...
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